chronic obstructive pulmonary disease (COPD) is a leading cause of chronic morbidity. The American Thoracic Society has defined COPD as "an obstruction to airflow chronic bronchial injury or emphysema, airflow obstruction is usually progressive and may be partially reversible." Respiratory Society Europe has defined COPD as "a reduced peak flow with a slow forced emptying of the lungs, the airflow limitation is slowly progressive and largely irreversible current medical treatment." More recently, the global initiative against chronic obstructive pulmonary disease (GOLD) defines COPD as "a disease characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and be associated with an abnormal inflammatory response of the lungs to noxious particles or gases. " Varies, however, the precise classification of airflow reversibility and severity of the disease. The differences in definition can cause variations in the calculations above 200%.
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