Saturday, December 4, 2010

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I / D polymorphism of ACE gene and cardiac hypertrophy in elite sport

A study published in the latest edition of English Journal of Cardiology (REC), whose intent is to determine the relationship between Polymorphism insertion / deletion of the gene for angiotensin converting enzyme (ACE) and adaptation to training high-level English athletes, reveals its involvement in the formation of cardiac hypertrophy in elite athletes. Stands out as the most frequent genotype heterozygous DI, present in approximately 56% of cases, the DD homozygotes, about 32% of cases, and genotype II, present in 11% of athletes tested.


According to Dr. Araceli Boraita, a cardiologist at the Center for Sports Medicine of the CSD and one of the main authors of the study, "the study reveals that those who have the DI genotype and, therefore, the D allele are the have a higher and better able to adapt to the sport. " "As far as we could say," he continued, "that having the D allele seems to predispose for sports."

Other highlights and revealing study are that the hypertrophy that occurs in these athletes is greater the higher the oxygen consumption experienced in the sport, and these athletes who have better cardiovascular adaptation, although the degree of presence of some other genotypes may vary Depending on the sport to practice.

In this regard it is noteworthy that in Spain, the sports that are most prevalent hypertrophy canoeing, triathlon, boxing, road cycling and rowing. In these disciplines, cases of hypertrophy in men would total 38%, while women would be about 28% of cases. This is because, says Dr. Boraita, that the woman "has 15% less muscle mass, so that the development of hypertrophy is less common. " On the other hand, says, "sports like football or basketball would be at an intermediate level, hypertrophy is also subject to post player."

The study, prepared by members of the Center for Sports Medicine of the CSD, the cardiology department of the Hospital Universitario de Canarias and genetics laboratory at the Institute of Tropical Diseases and Public Health of the Canary Islands has made a total of 299 elite athletes (193 men and 106 women, each with an average age of about 24 years), 32 different disciplines during the season 2007-2008 went to the Sports Medicine Center of the Sports Council for a medical-sports.

physiological hypertrophy of the athlete is well known and occurs when the athlete is subjected to high intensity aerobic exercise and maintained over time. Physical exercise activates the renin-angiotensin-aldosterone system (RAAS), a hormone that helps regulate blood pressure and body extracellular volume, so that their overstimulation during long periods has been associated with the development of left ventricular hypertrophy .

The fact that not all athletes with a similar degree of training to acquire the same degree hypertrophy has always suspect the possible involvement of genetic factors in heart size.

English Society of Cardiology (SEC)

The English Society of Cardiology (SEC) is a nonprofit scientific and professional organization dedicated to increasing the state of knowledge about the heart and circulatory system, to advance the prevention and treatment of their disease and improve survival and quality of life for cardiac patients.

The SEC has among its main objectives to contribute to international research, especially Europe and Latin America, creating national and international links development of actions, and representing all professionals interested in the area of \u200b\u200bcardiology.

http://www.diariosalud.net/content/view/20273/413/

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